notes

Nucleotide Excision Repair

Nucleotide excision repair is a DNA repair mechanism. DNA damage occurs constantly because of chemicals (e.g. intercalating agents), radiation and other mutagens. Three excision repair pathways exist to repair single stranded DNA damage: Nucleotide excision repair (NER), base excision repair (BER), and DNA mismatch repair (MMR). While the BER pathway can recognize specific non-bulky lesions in DNA, it can correct only damaged bases that are removed by specific glycosylases. Similarly, the MMR pathway only targets mismatched Watson-Crick base pairs.
核苷酸切除修复是一种DNA修复机制。由于化学物质(如插入剂)、辐射和其他诱变剂的作用，DNA损伤不断发生。修复单链DNA损伤有三种切除修复途径:核苷酸切除修复(NER)、碱基切除修复(BER)和DNA错配修复(MMR)。虽然BER通路可以识别DNA中特定的非大块头损伤，但它只能纠正被特定的糖基化酶移除的受损碱基。同样，MMR通路只针对不匹配的沃森-克里克碱基对。