15、Genomic Measurement, Sequencing, and Bioinformatics: An In - Depth Exploration

Genomic Measurement, Sequencing, and Bioinformatics: An In - Depth Exploration

1. Genomic Measurement Methods

1.1 FISH (Fluorescent In Situ Hybridization)

FISH is a genomic measurement method based on hybridization. Its main applications are three - fold:
- Detecting specific genes within chromosomes, including their location and count.
- Determining whether individual cells are missing or have extra chromosomes.
- Creating a color map of a cell’s chromosomes (karyotyping).

Although FISH tests have been partly replaced by other tests, they are still used for specific applications. As with most hybridization - based methods, strict protocol adherence and well - trained technicians are crucial for accurate results.

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