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RSS订阅原创 使用WPS生成自动目录，设置目录页码数字大小一致，页眉根据正文章节标题自动变化
提示：文章写完后，目录可以自动生成，如何生成可参考右边的帮助文档文章目录前言一、目录生成及页码数字大小一致二、使用步骤1.引入库2.读入数据总结前言提示：这里可以添加本文要记录的大概内容：主要记录自己使用wps时，word的目录自动生成方法，调整目录页码数字大小一致；以及页眉内容随正文的大章节更改，页码的设置，方便以后自己查看提示：以下是本篇文章正文内容，下面案例可供参考一、目录生成及页码数字大小一致要自动生成目录，首先要设置标题的样式，根据你想要的标题样式，设置1，2，3等级别标题.
2022-03-21 19:46:21
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原创 Cytoscape软件使用之STRING的PPI文本文件导入画连通图
最近在用cytoscape软件分析我DGEs的蛋白互作网络图，用到了这个软件中的节点和边的设置，以及网络节点根据各种算法来布局。下面我将按照五个部分来介绍，分别是数据导入，节点设置，边设置，布局展示，图片/文件导出。说明下我的cytoscape是3.7.1的，安装的时候java环境是jdk8一、数据导入 1、我们事先在STRING网站输入已经整理好的差异表达基因，然后会生成一个网络图，同时生成一个.tsv的文件，把这个文件下载下来，用Excel打开，里面就有我们连通的节点，以及其他属...
2021-03-10 22:08:17
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原创 linux下下载和安装lftp
之前下载sra数据的方法不行，后来看了一篇博客说用lftp，于是就开始捣鼓下载安装。1、linux服务器下载和安装lftp整个代码如下wget http://lftp.yar.ru/ftp/lftp-4.9.2.tar.gztar -xvf lftp-4.9.2.tar.gzcd lftp-4.9.2.tar.gz./configure --prefix="/software/lftp-4.9.2/usr/local"说明：1）压缩包是下载在我服务器software目录下的，所以上面的代
2020-12-06 15:25:23
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原创 Windows系统下载SRA数据，使用sratoolkit工具
上次写了在linux环境下从ncbi下载sra文件，这次因为ncbi的这个网站找不到ftp://ftp.ncbi.nlm.nih.gov/sra/sra-instant/reads/ByRun/sra/SRR造成我在linux环境下不能使用aspera下载，只好在Windows下，下载了再上传到linux服务器。一、工具下载1.从ncbi下载sratoolkit工具，打开ncbi，到这个界面根据系统下载你需要的sratoolkit，我是Windows 64位，于是就是下载倒数第二个。2.下载
2020-09-14 20:57:51
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原创 RStudio里面package存放路径更改及GEOquery包下载和GEO数据下载
一、首先是我的R和RStudio都不是默认安装路径，是安装在其他盘。很讨厌把东西都放在C盘，所以RStudio下载的package也不喜欢放在C盘，于是按照下面操作更改package存放目录。1.打开RStudio，在控制台输入.libPaths()，会显示如下结果，这是默认的package存放目录。.libPaths()#[1] "C:/Users/chan/Documents/R/win-library/4.0"#[2] "D:/Program Files/R/R-4.0.0/librar
2020-06-02 18:53:30
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原创 Linux下把sra文件转成fastq文件
记录下自己在安装sratoolkit和转换文件的摸索步骤转换文件需要使用sratoolkit软件，所以首先要下载，先说下下载、解压、安装这个软件。我事先在我的Linux目录下新建一个文件夹software用来存放下载的软件，新建文件夹命令：mkdir software，然后就在这个文件夹下载软件了。1. 在Linux下直接用wget来下载，输入如下命令：wget http://ftp...
2019-10-25 21:04:54
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原创 linux下使用Aspera Connect、wget和lftp下载sra数据
参考链接：https://www.jianshu.com/p/680e8d7205161. 下载Aspera Connect：在命令行输入如下命令wget http://download.asperasoft.com/download/sw/connect/3.7.4/aspera-connect-3.7.4.147727-linux-64.tar.gz2. 解压：tar zxvf...
2019-10-11 21:52:59
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原创 Tlr7缺失改变与神经功能相关的基因的表达谱并调节小鼠行为和情境记忆
Tlr7 deletion alters expression profiles of genes related to neural function and regulates mouse behaviors and contextual memoryTlr7：Toll样受体7，Toll-like receptors 7。Toll样受体（Toll-like receptors, TLR）是...
2019-08-05 17:54:05
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原创 来自人和大鼠大脑转录组的关于生长因子信号通路在重度抑郁症中失调的跨物种证据
Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depressionAn enhanced understanding of the pathophysiology of depression woul...
2019-08-05 16:56:35
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原创 Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus
雌激素在癫痫持续状态期间保护神经传递转录组Women with epilepsy commonly have premature onset of menopause. The decrease in estrogen levels is associated with increased occurrence of neurodegenerative processes and cognit...
2019-08-05 16:10:06
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原创 新的生物信息学方法识别人类背外侧前额叶皮层不同位点谱系特异性转座因子的转录谱
Novel Bioinformatics Approach Identifies Transcriptional Profiles of Lineage-Specific Transposable Elements at Distinct Loci in the Human Dorsolateral Prefrontal CortexExpression of transposable el...
2019-07-26 17:27:00
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原创 Genetics Factors in Major Depression Disease
重度抑郁症的遗传因素Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology. According to the World Health Organization, about 350 million people in the world are affected by ...
2019-07-26 15:43:52
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原创 外周血转录组共表达网络分析确定老年人内质网蛋白加工失调和复发性重度抑郁症的免疫反应
Co-expression network analysis of peripheral blood transcriptome identifies dysregulated protein processing in endoplasmic reticulum and immune response in recurrent MDD in older adultsThe molecular...
2019-07-26 10:59:18
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原创 抑郁自杀头侧前扣带回皮层中长链非编码RNA的表达
Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicidesLong non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in p...
2019-07-26 10:20:48
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原创 BDNF Val66Met基因型与雌二醇反向添加的跨物种模型中的经前焦虑障碍转录组的表观遗传相交
Epigenetic intersection of BDNF Val66Met genotype with premenstrual dysphoric disorder transcriptome in a cross-species model of estradiol add-backBDNF：脑源性神经营养因子Premenstrual dysphoric disorder (PM...
2019-07-25 18:11:52
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原创 25-羟基胆固醇通过p53 / SREBF2/NFYA 信号传导途径下调氧化固醇结合蛋白2（OSBPL2）
25-hydroxycholesterol down-regulates oxysterol binding protein like 2 (OSBPL2) via the p53 / SREBF2 / NFYAA signaling pathway.人体抑癌基因/固醇调节因子结合蛋白2Oxysterol Binding Protein Like 2 (OSBPL2) is a lipi...
2019-07-25 17:31:05
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原创 情绪和甲基化研究的研究设计和理论基础：双胞胎抑郁症的多组学研究平台
Study Design and Rationale for the Mood and Methylation Study: A Platform for Multi-Omics Investigation of Depression in TwinsMajor depression is a complex disorder with no single, direct causal mec...
2019-07-25 16:45:23
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原创 GABA-modulating bacteria of the human gut microbiota（GABA调节人肠道微生物群的细菌）
The gut microbiota affects many important host functions, including the immune response and the nervous system1. However, while substantial progress has been made in growing diverse microorganisms of ...
2019-07-25 16:04:43
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原创 Transcriptomic predictors of inflammation-induced depressed mood（炎症诱导抑郁情绪的转录组预测因子）
Inflammation plays a significant role in the pathophysiology of depression. However, not all individuals exposed to inflammatory challenge develop depression, and identifying those at risk is necessar...
2019-07-25 11:49:33
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原创 用PrediXcan基因型数据预测基因表达的准确性在大陆人群之间和内部各不相同
Transcriptomic predictors of inflammation-induced depressed moodUsing genetic data to predict gene expression has garnered significant attention in recent years. PrediXcan has become one of the most...
2019-07-25 10:46:11
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原创 电针改善抑郁症母体分离大鼠临床表现的转录组分析
Transcriptome Analysis on Maternal Separation Rats With Depression-Related Manifestations Ameliorated by Electroacupuncture.Maternal separation (MS), a stressful event in early life, has been linked...
2019-07-25 09:24:33
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原创 Multi-tissue transcriptome analyses identify genetic mechanisms underlying neuropsychiatric traits
多组织转录组分析确定神经精神特征的遗传机制The genetic architecture of psychiatric disorders is characterized by a large number of small-effect variants1 located primarily in non-coding regions, suggesting that the under...
2019-07-24 17:10:42
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原创 Transcriptome Changes in Relation to Manic Episode（转录组变化与躁狂发作的关系）
Bipolar disorder (BD) is highly heritable and well known for its recurrent manic and depressive episodes. The present study focused on manic episode in BD patients and aimed to investigate state-speci...
2019-07-24 16:01:06
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原创 Additive antidepressant-like effects of fasting with β-estradiol in mice（β-雌二醇禁食对小鼠抗抑郁作用的研究）
Our recent study has shown that acute fasting produces antidepressant-like effects in male mice. However, there is little evidence regarding the antidepressant-like effects of acute fasting in female ...
2019-07-24 11:09:15
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原创 The importance of long non-coding RNAs in neuropsychiatric disorders（ 长链非编码RNAs在神经精神疾病中的重要性）
In the last decade,transcriptomeanalyses have discovered thousands of long non-coding RNAs (lncRNAs) which are assumed as a fundamental part of the gene regulatory networks in the cell. Intriguingly...
2019-07-23 21:56:50
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转载 c++ STL 入门知识
最近要准备CSP认证，了解到掌握STL对认证有很大帮助，于是百度看到有个博主写的比较全面，想把他的借鉴过来，记录在自己的博客中，方便后续需要时可以查找。这里附上原博的链接：https://www.cnblogs.com/skyfsm/p/6934246.html原博中有一点错误，在vector介绍中，原博有句话写：vector<int> v10(4); //默认初始化为空字符串，这...
2018-09-13 09:16:37
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网络聊天程序私聊和群聊
2018-06-06
ping程序，c++编写，在vc++6.0上实现
2018-01-01
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