蛋白质亚硝基化修饰位点预测工具 —— GPS-SNO 1.0

最新推荐文章于 2025-07-25 11:51:53 发布

原创

最新推荐文章于 2025-07-25 11:51:53 发布 · 3.8k 阅读

0 ·

CC 4.0 BY-SA版权

文章标签：

#工具 #performance #algorithm #transition #validation #system

GPS-SNO 1.0是一款用于预测蛋白质亚硝基化修饰位点的计算软件，基于改进的GPS 3.0算法。该工具通过收集实验验证的数据进行训练，表现出优于其他方法的预测性能。在线服务和本地包已免费提供。

GPS-SNO: Computational prediction of protein S -nitrosylation sites with a modified GPS algorithm. Yu Xue , Zexian Liu, Xinjiao Gao, Changjiang Jin, Longping Wen, Xuebiao Yao, and Jian Ren . Plos One . 2010;5(6):e11290 [Full Text] [PDF]

The 1998 Nobel Prize in Physiology or Medicine was awarded for seminal discoveries that nitric oxide (NO) is a freely-diffusible signalling molecule and second messenger, regulates the production of cyclic GMP (cGMP), and plays essential roles in the cardiovascular system. Later, flood of studies challenged this fundamental view by observing that NO could spatially and temporally target specific cysteine thiols and transition metals of proteins, a reversib