C++ struct initialize memset?

Those two constructs a very different in their meaning. The first one uses a memset function, which is intended to set a buffer of memory to certain value. The second to initialize an object. Let me explain it with a bit of code:

Lets assume you have a structure that has members only of POD types

struct POD_OnlyStruct
{
    int a;
    char b;
};

POD_OnlyStruct t = {};  // OK

POD_OnlyStruct t;
memset(&t, 0, sizeof t);  // OK as well

In this case writing a POD_OnlyStruct t = {} or POD_OnlyStruct t; memset(&t, 0, sizeof t)doesn't make much difference, as the only difference we have here is the alignment bytes being set to zero-value in case of memset used. Since you don't have access to those bytes normally, there's no difference for you.

On the other hand, since you've tagged your question as C++, let's try another example, with membertypes different from POD:

struct TestStruct
{
    int a;
    std::string b;
};

TestStruct t = {};  // OK

{
    TestStruct t1;
    memset(&t1, 0, sizeof t1);  // ruins member 'b' of our struct
}  // Application crashes here

In this case using an expression like TestStruct t = {} is good, and using a memset on it will lead to crash. Here's what happens if you use memset - an object of type TestStruct is created, thus creating an object of type std::string, since it's a member of our structure. Next, memset sets the memory where the object b was located to certain value, say zero. Now, once our TestStruct object goes out of scope, it is going to be destroyed and when the turn comes to it's member std::string byou'll see a crash, as all of that object's internal structures were ruined by the memset.

So, the reality is, those things are very different, and although you sometimes need to memset a whole structure to zeroes in certain cases, it's always important to make sure you understand what you're doing, and not make a mistake as in our second example.

My vote - use memset on objects only if it is required, and use the default initialization x = {} in all other cases.

In some compilers STRUCT theStruct = {}; would translate to memset( &theStruct, 0, sizeof( STRUCT ) ); in the executable. Some C functions are already linked in to do runtime setup so the compiler have these library functions like memset/memcpy available to use.