Zymosan A (Zymosan A from Saccharomyces cerevisiae) 是一种 TLR2 激动剂 |MedChemExpress (MCE)

中文名：酵母聚糖A

CAS：58856-93-2

品牌：MedChemExpress (MCE)

存储条件：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

生物活性：Zymosan A (Zymosan A from Saccharomyces cerevisiae) 是一种 TLR2 激动剂，靶向 TLRs 可以预防和抑制 IR 诱导的肠道损伤。Zymosan A 具有明显的辐射防护作用，对小鼠辐照引起的肠道损伤具有保护作用。Zymosan A 促进 IR 损伤后肠干细胞 (ISCs) 的再生。

体内：Zymosan A 可用于动物建模，构建小鼠腹膜炎模型。Zymosan A (25.0 mg/kg；腹腔注射，IR 胁迫前 12 h 和 2 h) 减轻 IR 诱导的小鼠肠道损伤[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 20.0 Gy abdominal irradiation (ABI) model in mice[1] Dosage: 25.0 mg/kg, dissolved in NS Administration: IP; injection at 12 and 2 h before IR Result: Significantly reduced the degree of bleeding and edema in the intestinal tissue.

 参考详情：Zymosan A (Zymosan A from Saccharomyces cerevisiae) | TLR2激动剂 | MCE

参考文献：

[1]. Du J, et al. Zymosan-A promotes the regeneration of intestinal stem cells by upregulating ASCL2. Cell Death Dis. 2022 Oct 20;13(10):884.