Human Gene Functions POJ - 1080

本文介绍了一种用于计算基因序列相似性的算法,通过插入空格使两个基因序列等长,然后根据给定的评分矩阵计算最大匹配得分。算法采用动态规划的方法,通过构建二维dp数组来实现效率优化。

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题目链接:https://vjudge.net/problem/POJ-1080
题目:It is well known that a human gene can be considered as a sequence, consisting of four nucleotides, which are simply denoted by four letters, A, C, G, and T. Biologists have been interested in identifying human genes and determining their functions, because these can be used to diagnose human diseases and to design new drugs for them.

A human gene can be identified through a series of time-consuming biological experiments, often with the help of computer programs. Once a sequence of a gene is obtained, the next job is to determine its function.
One of the methods for biologists to use in determining the function of a new gene sequence that they have just identified is to search a database with the new gene as a query. The database to be searched stores many gene sequences and their functions – many researchers have been submitting their genes and functions to the database and the database is freely accessible through the Internet.

A database search will return a list of gene sequences from the database that are similar to the query gene.
Biologists assume that sequence similarity often implies functional similarity. So, the function of the new gene might be one of the functions that the genes from the list have. To exactly determine which one is the right one another series of biological experiments will be needed.

Your job is to make a program that compares two genes and determines their similarity as explained below. Your program may be used as a part of the database search if you can provide an efficient one.
Given two genes AGTGATG and GTTAG, how similar are they? One of the methods to measure the similarity
of two genes is called alignment. In an alignment, spaces are inserted, if necessary, in appropriate positions of
the genes to make them equally long and score the resulting genes according to a scoring matrix.

For example, one space is inserted into AGTGATG to result in AGTGAT-G, and three spaces are inserted into GTTAG to result in –GT–TAG. A space is denoted by a minus sign (-). The two genes are now of equal
length. These two strings are aligned:

AGTGAT-G
-GT–TAG

In this alignment, there are four matches, namely, G in the second position, T in the third, T in the sixth, and G in the eighth. Each pair of aligned characters is assigned a score according to the following scoring matrix.

denotes that a space-space match is not allowed. The score of the alignment above is (-3)+5+5+(-2)+(-3)+5+(-3)+5=9.

Of course, many other alignments are possible. One is shown below (a different number of spaces are inserted into different positions):

AGTGATG
-GTTA-G

This alignment gives a score of (-3)+5+5+(-2)+5+(-1) +5=14. So, this one is better than the previous one. As a matter of fact, this one is optimal since no other alignment can have a higher score. So, it is said that the
similarity of the two genes is 14.
Input
The input consists of T test cases. The number of test cases ) (T is given in the first line of the input file. Each test case consists of two lines: each line contains an integer, the length of a gene, followed by a gene sequence. The length of each gene sequence is at least one and does not exceed 100.
Output
The output should print the similarity of each test case, one per line.
题意:给你俩个字符串,还有对应的长度,每个字符串都由A,C,G,T构成,让你对字符进行匹配,不同字母之间的匹配对应不同的值,也可以添加‘-’进行匹配,匹配后两个字符串应该是等长的,让你求最大的匹配值;
思路:用一个二维的dp数组,其中dp[i][j]代表第一个字符串x前i个字符与第二个字符串y前j个字符匹配后所能获得的最大值,当前的转态可以由三种状态转移过来,第一种,x[i]与y[j]相匹配,当前状态为dp[i-1][j-1]+匹配取值,第二种状态,x[i]与-匹配,当前状态为dp[i-1][j]+x[i]与-的匹配值,第三种状态,y[j]与-匹配,当前转态由dp[i][j-1]+y[j]与-的匹配值;然后在从三个里面取最大值就是当前状态的值;
AC代码:
int z[5][5]={5,-1,-2,-1,-3,
-1,5,-3,-2,-4,
-2,-3,5,-2,-2,
-1,-2,-2,5,-1,
-3,-4,-2,-1,0};
int y1()
{
for(int a=1;a<=num1;a++)
{
for(int b=1;b<=num2;b++)
{
dp[a][b]=max(dp[a-1][b-1]+z[m[x[a]]][m[y[b]]],dp[a-1][b]+z[m[x[a]]][m[‘-‘]]);
dp[a][b]=max(dp[a][b],dp[a][b-1]+z[m[‘-‘]][m[y[b]]]);
}
}
return dp[num1][num2];
}
int main()
{
m[‘A’]=0;
m[‘C’]=1;
m[‘G’]=2;
m[‘T’]=3;
m[‘-‘]=4;
int t;
scanf(“%d”,&t);
while(t–)
{
scanf(“%d”,&num1);
scanf(“%s”,x+1);
scanf(“%d”,&num2);
scanf(“%s”,y+1);
dp[0][0]=0;
for(int a=1;a<=num1;a++)
dp[a][0]=dp[a-1][0]+z[m[x[a]]][m[‘-‘]];
for(int a=1;a<=num2;a++)
dp[0][a]=dp[0][a-1]+z[m[‘-‘]][m[y[a]]];
printf(“%d\n”,y1());
}
}

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