L-色氨酸 (Tryptophan) 是一种必需氨基酸，是血清素、褪黑激素和维生素 B3 的前体 | MedChemExpress (MCE)

L-Tryptophan

中文名：L-色氨酸

CAS：73-22-3

品牌：MedChemExpress (MCE)

存储条件：4°C, protect from light, stored under nitrogen

生物活性：L-色氨酸 (Tryptophan) 是一种必需氨基酸，是血清素、褪黑激素和维生素 B3[1] 的前体。

体外：L-Tryptophan (Tryptophan；500、1000 μM；48 小时) 高剂量下可显着抑制 pTr2 细胞增殖并增加细胞周期 G1 期的细胞百分比[1]。 L-Tryptophan (10 μM；持续三周) 增强 hBMSC 的体外迁移、集落形成和成骨分化[2]。 L-Tryptophan (10 μM；持续三周) 降低脂肪形成标志物 PPARγ 和 LPL 的 mRNA 水平[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：L-Tryptophan (Tryptophan；10、50 kg/mg/天；腹膜内注射；连续三周) 以 50 mg/kg/天可增强 mBMSC 体内的迁移、集落形成和成骨分化[2]。 L-Tryptophan (50 毫克/公斤/天；腹腔注射；连续三周) 加速小鼠股骨手术缺损的骨再生[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Five-week-old C57BL/6 mice[2] Dosage: 10, 50 kg/mg Administration: Intraperitoneally; daily; for consecutive three weeks Result: The concentration of 50 mg/kg/day induced a significant increase in the number of SSEA-4 positive cells. Increased the mRNA levels of Nanog and Oct-4 and the colony-forming ability of mBMSCs with 50 mg/kg/day. Clinical Trial

参考文献：

[1]. Slominski A, et al. Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells. FEBS Lett. 2002 Jan 30;511(1-3):102-6.
[2]. Kang Xu, et al. L-Tryptophan activates the aryl hydrocarbon receptor and induces cell cycle arrest in porcine trophectoderm cells. Theriogenology. 2021 Sep 1:171:137-146.
[3]. Hai Thanh Pham, et al. Tryptophan and Kynurenine Enhances the Stemness and Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro and In Vivo. Materials (Basel). 2021 Jan 4;14(1):208.