Amivantamab (JNJ-61186372) 是一种人源 EGFR-MET 双特异性抗体 ｜ MedChemExpress (MCE)

Amivantamab

CAS：2171511-58-1

品牌：MedChemExpress (MCE)

存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.

生物活性：Amivantamab (JNJ-61186372) 是一种人源 EGFR-MET 双特异性抗体，具有免疫抗癌活性。Amivantamab 可以抑制配体结合，促进受体-抗体复合物的内吞作用和降解，并诱导巨噬细胞的 Fc 依赖性胞吞作用和自然杀伤细胞的抗体依赖性细胞毒性。

体外：Amivantamab (JNJ-61186372)(0.05-1 mg/mL) 导致 Ba/F3 细胞活力显着且剂量依赖性降低，EGFR 下游信号通路磷酸化 EGFR (pEGFR)、磷酸化 AKT (pAKT)、磷酸化 ERK (pERK) 和磷酸化 S6 (pS6) 也显着降低[2]。 Amivantamab (JNJ-61186372) 可以通过下调 EGFR 和 MET 信号通路在具有 EGFR Exon20ins 突变的 NSCLC 患者来源的癌细胞中具有有效的抗肿瘤活性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Amivantamab (JNJ-61186372) (i.p, 30 mg/kg, twice a week, 15 days) 可以有效减小在雌性无胸腺 BALB-c/nu 小鼠的 EGFR Exon20ins 突变的 NSCLC 异种移植模型中的肿瘤体积，具有体内抗肿瘤作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Clinical Trial

参考文献：

[1]. Keunchil Park, et al. Amivantamab in EGFR Exon 20 Insertion-Mutated Non-Small-Cell Lung Cancer Progressing on Platinum Chemotherapy: Initial Results From the CHRYSALIS Phase I Study. J Clin Oncol. 2021 Oct 20;39(30):3391-3402.
[2]. Jiyeon Yun, et al. Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR-MET Bispecific Antibody, in Diverse Models of EGFR Exon 20 Insertion-Driven NSCLC. Cancer Discov. 2020 Aug;10(8):1194-1209.