UCSD计算生物学——1.Introduction

本文介绍了UCSD的计算生物学课程,强调其在入门生物信息学中的重要性,涵盖基因组学、转录组学、蛋白质组学和代谢组学的基本概念。内容包括DNA复制过程、从DNA到蛋白质的转换,以及生物信息学在寻找隐藏信息、确定疾病原因等方面的应用。同时,提到了常用的生物信息学数据集ICGC。

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课程名称:Bioinformatics Algorithm: An active learning approach

Instructor: Dr. PABLO & Dr. Phillips Campos

UCSD的课程,对入门计算生物学有特别大的帮助。 教学视频来自于Youtube。 在Coursera上也有该课程,但是有规定的时间安排,来不及看。

该博客将关注该课程的知识要点,配套Biopython的代码实现,参考经典书籍(列举如下),给自己以督促,以飨有需之人。


参考书籍:

1. Bioinformatics Sequence and Genomic Analysis

2. An Introduction of Bioinformatic Algorithm

(经师兄推荐目前在参考这两本书。据说前者更加偏向生物科学方面,后者更加注重算法的研究)

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Introduction:

计算生物学:多用字符串查找,图论和机器学习的知识解决基因序列等生物学上的问题。问题包括:

1.生物序列的片段拼接。
2.序列对接。
3.基因识别:
人类长达30个亿DNA序列中只有3%-5%是基因。阐明人体中全部基因的位置,结构,功能,表达等。
4.蛋白质结构预测
BIOINFORMATICS ALGORITHMS,VOL.I By 作者: Phillip Compeau – Pavel Pevzner ISBN-10 书号: 0990374610 ISBN-13 书号: 9780990374619 Edition 版本: 2nd 出版日期: 2015 pages 页数: 384 Overview Contents List of Code Challenges About the Textbook Chapter 1:Where in the Genome Does DNA Replication Begin? Chapter 2:Which DNA Patterns Play the Role of Molecular Clocks? Chapter 3:How Do We Assemble Genomes? Chapter 4:How Do We Sequence Antibiotics? Chapter 5:How Do We Compare DNA Sequences? Chapter 6:Are There Fragile Regions in the Human Genome? Bibliography mage Courtesies This is Vol. 1 of Bioinformatics Algorithms: an Active Learning Approach, one of the first textbooks to emerge from the recent Massive Open Online Course MOOC revolution. A light hearted and analogy filled companion to the author’s acclaimed Bioinformatics Specialization on Coursera, this book presents students with a dynamic approach to learning bioinformatics. It strikes a unique balance between practical challenges in modern biology and fundamental algorithmic ideas, thus capturing the interest of students of both biology and computer science. Each chapter begins with a biological question, such as Are There Fragile Regions in the Human Genome or Which DNA Patterns Play the Role of Molecular Clocks and then steadily develops the algorithmic sophistication required to answer this question. Hundreds of exercises are incorporated directly into the text as soon as they are needed; readers can test their knowledge through automated coding challenges on the Rosalind Bioinformatics Textbook Track.
BIOINFORMATICS ALGORITHMS,VOL.II By 作者: Phillip Compeau – Pavel Pevzner ISBN-10 书号: 0990374629 ISBN-13 书号: 9780990374626 Edition 版本: 2nd 出版日期: 2015 pages 页数: 320 This is Vol. 2 of Bioinformatics Algorithms: an Active Learning Approach, one of the first textbooks to emerge from the recent Massive Open Online Course (MOOC) revolution. A light-hearted and analogy-filled companion to the authors’ acclaimed Bioinformatics Specialization on Coursera (http://coursera.org/specialization/bioinformatics/34), this book presents students with a dynamic approach to learning bioinformatics. It strikes a unique balance between practical challenges in modern biology and fundamental algorithmic ideas, thus capturing the interest of students of both biology and computer science. Each chapter begins with a biological question, such as “Are There Fragile Regions in the Human Genome?” or “Which DNA Patterns Play the Role of Molecular Clocks?” and then steadily develops the algorithmic sophistication required to answer this question. Hundreds of exercises are incorporated directly into the text as soon as they are needed; readers can test their knowledge through automated coding challenges on the Rosalind Bioinformatics Textbook Track (http://rosalind.info/problems/list-view/?location=bioinformatics-textbook-track). List of Code Challenges About the Textbook Chapter 7:Which Animal Gave Us SARS? Chapter 8:How Did Yeast Become a Wine Maker? Chapter 9:How Do We Locate Disease-Causing Mutations? Chapter 10:Why Have Biologists Still Not Developed an HIV Vaccine? Chapter 11:Was T.rex Just a Big Chicken? Bibliography Image Courtesies
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