神经系统病毒

Table 1

Classification, properties and CNS entry routes of viruses that can cause nervous system infections.

Genome	Virus Family	N/E	Specifics	Viruses	CNS Entry
dsDNA	Adenoviridae	N		MAV-1	BBB; BMVECs
	Herpesviridae	E	Alphaherpesvirus	HSV-1, HSV-2, VZV, PRV, BHV	sensory nerve endings, ORN
			Betaherpesvirus	HCMV	BBB; BMVECs
			Gammaherpesvirus	EBV	BBB; BMVECs
	Polyomaviridae	N		JCV	BBB; BMVECs
dsRNA	Reoviridae	N	mouse model	T3[1]	BBB, peripheral nerve?
(+)ssRNA	Coronaviridae	E	mouse model	MHV[2]	peripheral nerve, ORN
	Flaviviridae	E	Hepacivirus	HCV*	BBB, BMVECs
			zoonotic	WNV*, JEV*	peripheral nerve, BBB, ORN, BMVECs
	Picornaviridae	N	Enterovirus	Poliovirus*, EV71*	NMJs, BBB
			mouse model	TMEV[3]	BBB
	Togaviridae	E	zoonotic	CHIKV*	ORN?
			mouse model	SINV[4]	ORN
(−)ssRNA	Arenaviridae	E	zoonotic	LCMV	BBB
	Bornaviridae	E	zoonotic	BDV	ORN
	Bunyaviridae	E	zoonotic	LACV	ORN, BBB?
	Orthomyxoviridae	E	zoonotic	Influenza A*	peripheral nerve, ORN
	Paramyxoviridae	E	Morbilivirus	MV	BBB
			Rubulavirus	MuV	BBB
			Henipavirus (zoonotic)	HeV*, Nipah*	BBB, ORN?
	Rhabdoviridae	E	zoonotic	RabV, VSV	NMJs, ORN
ssRNA-RT	Retroviridae	E	Lentivirus	HIV*, HTLV	BBB