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RNA二级结构在 siRNA设计中的应用
RNA二级结构在 siRNA设计中的应用RNA二级结构在siRNA设计方面的应用以及分析其可能出现的功能目前关于RNA二级结构对siRNA沉默效率影响的研究主要包括两方面:siRNA与mRNA结合位点处的mRNA二级结构 ;siRNA自身的二级结构反义链：与靶区域序列互补的那条链正义链：与靶区域序列相同的那条链siRNA是短双链 RNA，反义链自身的二级结构可能对其形成RISC会...原创 2020-03-04 16:58:24 · 1981 阅读 · 0 评论 -
Demonstration of two novel methods for predicting functional siRNA efficiency
Demonstration of two novel methods for predicting functional siRNA efficiencyBackground: siRNAs is very important during the gene silencing process(RNAi),but the siRNA efficiency for targeting differ...原创 2020-03-04 16:57:49 · 423 阅读 · 1 评论 -
Prediction of siRNA functionality using generalized string kernel and support vector machine
Prediction of siRNA functionality using generalized string kernel and support vector machineAbstract:GSK+SVMGSK:generalized string kernelresult : classify effective and ineffective siRNAs use GSK ...原创 2020-03-04 16:57:15 · 301 阅读 · 0 评论 -
VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human viruses
VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human virusesBackground:Datasets:VIRsi-RNAdb:19merV345V^{345}V345: 345 sequences for validationT1380T^{1380}T138...原创 2020-03-04 16:56:34 · 5576 阅读 · 0 评论