PPI database：STRING VS IntAct VS IMEx

最新推荐文章于 2022-02-23 15:20:01 发布

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最新推荐文章于 2022-02-23 15:20:01 发布 · 878 阅读

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博客介绍了STRING、IntAct与IMEx三个蛋白交互数据库。STRING整合已知和预测的蛋白关联数据，有预测和实验数据，查询有数据损失；IntAct蛋白对来源可靠，可提供IMEx数据集下载，缺点是每次只能查一个蛋白；IMEx数据广泛、全面且可靠，需在IntAct网站下载。

S. Orchard et al., “Protein interaction data curation: The International Molecular Exchange (IMEx) consortium,” Nature Methods, vol. 9, no. 4, pp. 345-350, Apr 2012

Henning et al, IntAct: an open source molecular interaction database, Nucleic Acids Research, Volume 32, Issue suppl_1, 1 January 2004, Pages D452–D455,

Szklarczyk D, Franceschini A, Wyder S, et al. STRING v10: protein–protein interaction networks, integrated over the tree of life[J]. Nucleic acids research, 2015, 43(D1): D447-D452.

1. STRING

consolidating known and predicted protein–protein association data for a large number of organisms

STRING include direct (physical) interactions, as well as indirect (functional) interactions, as long as both are specific and biologically
meaningful.

data source: