摘要:
As part of the validation of any statistical model, it is good statistical practice to quantify the amount of prognostic information represented by the model; this includes gene expression signatures derived from high-dimensional microarray data. Several approaches exist for right-censored survival data that measure the gain in prognostic information compared to established clinical parameters or biomarkers in terms of explained variation or explained randomness. They are either model-based or use estimates of the prediction accuracy.
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