本文综述了胶质母细胞瘤的遗传、表观遗传、转录和蛋白质组学研究，强调了MGMT启动子甲基化、IDH1突变等分子改变的重要性和预后意义。这些发现有望为胶质母细胞瘤提供新的治疗靶点和个体化治疗策略。
摘要：
methylguanine-DNA methyltransferase (MGMT) promoter has been the only confirmed molecular predictive factor in glioblastoma. Novel "genome-wide" techniques have identified additional important molecular alterations as mutations in isocitrate dehydrogenase 1 () and its prognostic importance. This review summarizes findings and techniques of genetic, epigenetic, transcriptional, and proteomic studies of glioblastoma. It provides the clinician with an up-to-date overview of current identified molecular alterations that should ultimately lead to new therapeutic targets and more individualized treatment approaches in glioblastoma.
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