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INTRODUCTION The emergence of second generation direct-acting antivirals (DAAs) has radically changed the landscape of treatment of chronic hepatitis C virus (HCV) infection. A once-daily, single-tablet, pange334notypic regimen comprising velpatasvir, a NS5A inhibitor of HCV viral ribonucleic acid replication and virion assembly, and sofosbuvir, a HCV NS5B polymerase inhibitor, for 12 wk has proven highly effective a...

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!NTRODUCTION Treatment of CHB was revolutionized by the introduetion of orally administered antiviral agents·Lamivudine，a nudeoside analogand the first orally avallable antivjral agent fof CHB，had demonstrated significant results in clinieal trlals，withu亩versal suPPression of HBV DNA level by3 1095，55%improvementin址stolo乡cal necroinflammato尽 seore，normali，ation of ALT in tho majority of PatientS after 1 year of treat...

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涎腺恶性淋巴上皮病损(malignant lymphoepi-thehal lesions,M比L)又称为未分化癌伴淋巴样间质,是一种罕见的涎腺恶性肿瘤,好发于北美的爱斯基摩人、格陵兰人及南部中国人。MLEL与EPstein-Barr病毒(EBV)感染关系密切,它是否由良性淋巴上皮病损(beni,lymphoepithelial lesions,BLEL)恶变而来是有争议的。我们报道2例良性淋巴上皮病损灶性恶变(beni邵l卿phoepithelial lesions withfoealm滋i卯ant transformation,B比L一FMT)病例,并采用原位杂交、PCR方法对其良、恶性组织进行EBV编码的小分子RNA一1(EBER一l)及EBVBamHI一W片断检测,探讨EBV感染在良性淋巴上皮病损癌变发生中的作用。资料和方法.研究对象:2例BLEL一FMT、14例MLEL、4例中华口腔医学杂志2004年7月第39卷第4期...

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