signature=95b9cb67765fcf6a86461ce43255bd50,Immunogenic composition

元彦和

于 2021-05-30 17:59:01 发布

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该发明涉及一种免疫原复合物，包含来自艰难梭菌毒素A和毒素B的C末端域片段。特别是一种由至少90%同源的首个多肽（SEQIDNO:1或其变体）和至少80%同源的第二个多肽（SEQIDNO:2或其变体）组成的配方，其中第一多肽至少含有250个氨基酸，第二多肽长度可选范围从250到600。

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摘要：

The present invention relates to an immunogenic composition comprising a fragment of the C terminal domain of toxin A and a fragment of the C terminal domain of toxin B from Clostridium difficile, in particular the invention relates to an immunogenic composition comprising a first polypeptide and a second polypeptide wherein the first polypeptide comprises: (i) SEQ ID NO:1; (ii) a variant of SEQ ID NO:1 having at least 90%, 95%, 98%, 99% or 100% identity to SEQ ID NO:1;or (iii) a fragment of at least 250, 280 or 300 amino acids of SEQ ID NO:1; and wherein the second polypeptide comprises: (iv) SEQ ID NO:2; (v) a variant of SEQ ID NO:2 having at least 80%, 90%, 95%, 98%, 99% or 100% identity to SEQ ID NO:2; or (vi) a fragment of at least 250, 280, 300, 350, 400, 450, 500, 550 or 600 amino acids of SEQ ID NO:2.

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