signature=7ee3f73aed07a1df06aae23bd8bec686,Abstract 3563: Unlocking the potential of CD70 as a thera...

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于 2021-05-29 16:34:36 发布

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CD70-CD27信号通路激活NFκB，促进淋巴细胞增殖与存活。在恶性肿瘤中，CD70常过度表达，可能介导免疫逃逸。sCD27，CD27的胞外域，淋巴细胞活化后释放，其水平在淋巴瘤患者血清中升高。研究中首次系统探讨了CD70在非小细胞肺癌（NSCLC）中的表达情况。

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Introduction: Upon interaction of CD70, a type II transmembrane protein, with its receptor CD27, the NFκB pathway is activated, leading to proliferation and survival. Hence, CD70 expression is tightly regulated and only transient on cells of the lymphoid lineage. In contrast, constitutive overexpression of CD70 has been documented in malignancies, where it appears to mediate immune escape through recruitment of CD27+ regulatory cells. Soluble CD27 (sCD27), the extracellular domain of CD27, can be released after lymphocyte activation and has been detected at increased levels in serum samples of lymphoid malignancies. To our knowledge, expression of CD70 has never been systematically characterized in non-small cell lung cancer (NSCLC).

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