signature=a46e9b19419d1ae6cba9d12a867f54a1,Characterization of human αβTCR repertoire and discovery ...

赵智沉

于 2021-05-29 11:58:29 发布

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研究揭示了人T细胞受体（TCR）α链和β链库的复杂性差异，发现TCRα多样性高于β链，V和J基因偏好使用一致，TRDV1倾向于与多数TRAJ基因结合，同时在β链中发现约2%的串联TRBD现象。

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摘要：

The characterization of the human T-cell receptor (TCR) repertoire has made remarkable progress, with most of the work focusing on the TCRβ chains. Here, we analyzed the diversity and complexity of both the TCRα and TCRβ repertoires of three healthy donors. We found that the diversity of the TCRα repertoire is higher than that of the TCRβ repertoire, whereas the usages of the V and J genes tended to be preferential with similar TRAV and TRAJ patterns in all three donors. The V-J pairings, like the V and J gene usages, were slightly preferential. We also found that the TRDV1 gene rearranges with the majority of TRAJ genes, suggesting that TRDV1 is a shared TRAV/DV gene (TRAV42/DV1). Moreover, we uncovered the presence of tandem TRBD (TRB D gene) usage in ~2% of the productive human TCRβ CDR3 sequences.

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