signature=30a6c4dd01c70e855c76405cec312e39,Whole-transcriptome sequencing uncovers core regulatory m...

转载于 2021-05-29 21:01:17 发布 · 152 阅读

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本文研究发现FGR（胎儿生长受限）与对照组脐带血中存在显著不同的蛋白质编码基因（如S100A6和S100A4）、长非编码RNA（如LINC01291和LINC01293）及microRNA（13种）。这些差异可能在FGR的病理机制中起重要作用。

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摘要：

Significantly different transcriptome of FGR and control umbilical cord blood. – Hierarchical clustering analysis identified 339 protein coding genes ( ), 295 lncRNAs ( ), and 13 miRNAs ( ), that are differentially expressed between FGR and the corresponding control. Examples of critical protein coding genes (S100A6, S100A4) expressed in normal control that is repressed in FGR. Examples of critical lncRNAs (LINC01291, LINC01293) not expressed in normal control that becomes activated in FGR

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