一种使用光学纤维阵列设备筛选结合分子，特别是单克隆抗体的方法被披露。该方法涉及将目标细胞涂覆到微珠群体上，每个微珠上涂覆有相同类型的多个细胞，并与之关联的检测和报告标记。每个细胞涂层的微珠被置于光纤阵列一端的特定孔中，与结合分子接触后，通过光纤阵列的远端报告与微珠关联的检测结果。
摘要：
Disclosed is a method of screening binding molecules, including Monoclonal Antibodies, using an optical fiber array device. Target cells are coated onto a population of microbeads, wherein each microbead is coated with several cells of the same cellular type and has an assay and an assay reporter associated with it. Each of the cell-coated microbeads is positioned in a particular well formed in one end of a particular fiber in an array of optical fibers. The microbeads are contacted with binding molecules, and the results of an assay associated with a microbead are reported to the distal end of the array of fibers.
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