signature=21433beef0a4ccefb8b3c80dfcd60012,Genetic diversity and selection signatures of the beef ' ...-优快云博客

研究利用BovineSNP50芯片数据揭示了古巴查理奥牛(CHCU)的遗传结构，发现与欧洲查理奥牛(CHA)的分化以及可能的祖先起源。重点区域的基因可能影响免疫、代谢适应和热耐受性在CHCU，以及肌肉发育和肉质特性在CHA上的差异。这些发现有助于理解家畜对热带环境的分子适应过程和肉品质量相关基因。

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摘要：

In this study, we used BovineSNP50 Genotyping BeadChip data to estimate the structure, putative ancestral origin as well as to identify regions with selective sweeps that may have had an important role in the adaptation to tropical conditions of the 'Charolais de Cuba' (CHCU) breed. According to a principal component analysis, CHCU samples cluster together with taurine breeds with an estimated 93% oftaurusancestral alleles. Despite the short period since importation, we detected differentiation (Fst=0.049) between the French Charolaise (CHA) and CHCU. However, CHA breed was the closest breed to CHCU followed by other hybrids breed with a clear CHA origin. Linkage disequilibrium (r2) decay tends to be lower in CHCU compared to CHA probably due to a less intense artificial selection programs of CHCU. Signals of recent adaptation to tropical conditions between CHCU and CHA were identified. Genes mapping within those regions reflect different functions related to immunity, metabolic changes and heat tolerance (CHCU) and muscle development and meat quality (CHA) that may have had an important role in the phenotypic differentiation of these breeds. Further studies will expand our knowledge on the molecular basis of adaptation of cattle to tropical conditions and molecular process associated with meat quality traits.

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