The Chaos Inside a Cancer Cell _the member enum size can only be defined inside a -优快云博客

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许多癌症细胞的一个显著特征是其染色体内的DNA全部混乱。DNA片段被从原来的位置移除并重新插入到不同的位置或其他染色体上。这种重组可能会破坏细胞的调控系统，特别是当重组将某个基因切分为两部分或将其与控制其活性的DNA区域分离时。研究人员对比了一种乳腺癌细胞的基因组与正常细胞的基因组，发现了157处重组。

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The Chaos Inside a Cancer Cell

A striking feature of many cancer cells is that the DNA in their chromosomes is all jumbled up. Chunks of DNA containing one or more genes have been ripped out of their chromosome and reinserted in a different place. Other lengths of DNA have been transferred to a different chromosome altogether.

These rearrangements may degrade the cell's regulatory systems, especially when a rearrangement cuts a gene in half, or separates it from the regions of DNA that control its activity.

Researchers led by Oliver A. Hampton and Aleksandar Milosavljevic at the Baylor College of Medicine in Houston have now compared the genome of a type of breast cancer cell with that of normal cells. They find 157 rearrangements, they report in the current issue of Genome Research.

The graphic summarizes their results. Round the outer ring are shown the 23 chromosomes of the human genome. The lines in blue, in the third ring, show internal rearrangements, in which a stretch of DNA has been moved from one site to another within the same chromosome. The red lines, in the bull's eye, designate switches of DNA from one chromosome to another.

One of the rearrangements disrupts a gene called RAD51C which is involved in mending serious chromosome breaks, those in which both strands in the DNA are disrupted. The impairment of double strand break repair could be a major cause of all the other rearrangements, the researchers suggest.