蛋白质亚硝基化修饰位点预测工具 —— GPS-SNO 1.0

iteye_21202

于 2010-08-10 16:09:00 发布

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文章标签： java

GPS-SNO 1.0 是一个基于JAVA开发的软件，用于预测蛋白质的S-亚硝基化修饰位点。该工具通过改进的GPS 3.0算法提供高精度预测，可用于理解S-亚硝基化在生物过程和疾病中的作用。在实验验证的467个S-亚硝基化位点上，GPS-SNO 1.0表现出良好的预测性能，并提供了在线服务和本地包供研究者使用。

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GPS-SNO: Computational prediction of protein S -nitrosylation sites with a modified GPS algorithm. Yu Xue , Zexian Liu, Xinjiao Gao, Changjiang Jin, Longping Wen, Xuebiao Yao, and Jian Ren . Plos One . 2010;5(6):e11290 [Full Text] [PDF]

The 1998 Nobel Prize in Physiology or Medicine was awarded for seminal discoveries that nitric oxide (NO) is a freely-diffusible signalling molecule and second messenger, regulates the production of cyclic GMP (cGMP), and plays essential roles in the cardiovascular system. Later, flood of studies challenged this fundamental view by observing that NO could spatially and temporally target specific cysteine thiols and transition metals of proteins, a reversibly post-translational modification (PT