Android Studio-Didn't find class XXX on path: DexPathList [zip file "/data/xxx/base.apk]解决方法

OPPO R11 手机运行应用，打开app直接闪退，界面进都进不去。错误信息如下：

    --------- beginning of crash
2019-03-22 13:33:21.065 22665-22665/com.guagua.guagua E/AndroidRuntime: FATAL EXCEPTION: main
    Process: com.guagua.guagua, PID: 22665
    java.lang.RuntimeException: Unable to instantiate application com.guagua.commerce.LiveApplication: java.lang.ClassNotFoundException: Didn't find class "com.xxx.xxx.XxApplication" on path: DexPathList[[zip file "/data/app/com.xxx.xxx-2/base.apk"],nativeLibraryDirectories=[/data/app/com.xxx.xxx-2/lib/arm, /data/app/com.xxx.xxx-2/base.apk!/lib/armeabi-v7a, /system/lib, /vendor/lib]]
        at android.app.LoadedApk.makeApplication(LoadedApk.java:853)
        at android.app.ActivityThread.handleBindApplication(ActivityThread.java:5748)
        at android.app.ActivityThread.-wrap2(ActivityThread.java)
        at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1716)
        at android.os.Handler.dispatchMessage(Handler.java:102)
        at android.os.Looper.loop(Looper.java:185)
        at android.app.ActivityThread.main(ActivityThread.java:6615)
        at java.lang.reflect.Method.invoke(Native Method)
        at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:916)
        at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:806)
     Caused by: java.lang.ClassNotFoundException: Didn't find class "com.xxx.xxx.XxApplication" on path: DexPathList[[zip file "/data/app/com.xxx.xxx-2/base.apk"],nativeLibraryDirectories=[/data/app/com.guagua.guagua-2/lib/arm, /data/app/com.xxx.xxx-2/base.apk!/lib/armeabi-v7a, /system/lib, /vendor/lib]]
        at dalvik.system.BaseDexClassLoader.findClass(BaseDexClassLoader.java:56)
        at java.lang.ClassLoader.loadClass(ClassLoader.java:380)
        at java.lang.ClassLoader.loadClass(ClassLoader.java:312)
        at android.app.Instrumentation.newApplication(Instrumentation.java:993)
        at android.app.LoadedApk.makeApplication(LoadedApk.java:847)
        at android.app.ActivityThread.handleBindApplication(ActivityThread.java:5748) 
        at android.app.ActivityThread.-wrap2(ActivityThread.java) 
        at android.app.ActivityThread$H.handleMessage(ActivityThread.java:1716) 
        at android.os.Handler.dispatchMessage(Handler.java:102) 
        at android.os.Looper.loop(Looper.java:185) 
        at android.app.ActivityThread.main(ActivityThread.java:6615) 
        at java.lang.reflect.Method.invoke(Native Method) 
        at com.android.internal.os.ZygoteInit$MethodAndArgsCaller.run(ZygoteInit.java:916) 
        at com.android.internal.os.ZygoteInit.main(ZygoteInit.java:806) 

这个错误很尴尬，只在OPPO手机上出现，别的手机上不会出现. 最后解决方法是，关闭 AS的 Instant Run就好了。
关闭AS InstallRun的方法如下：
打开AS设置界面，然后找到Build->Execution, 取消勾选就OK了。

转载请注明出处，非常感谢。https://blog.youkuaiyun.com/guiping_ding/article/details/88739421