ENZO ELISA试剂盒：Rat Leptin ELISA kit

瘦素(Leptin)是由ob基因编码、在脂肪组织中生成的一种脂肪代谢调控产物，在代谢和调控体重等方面发挥重要作用。它通过下丘脑中的瘦素受体发出信号，降低食欲，增加能量消耗。在外周组织中，瘦素能拮抗胰岛素信号传导，增加脂肪酸氧化，减少胰岛β细胞的胰岛素分泌，并促进生育。它在脂肪细胞中的表达可以被其他脂肪因子如IL-6（刺激）和TNF-α（抑制）以旁分泌方式调节。瘦素缺乏的小鼠表现出严重的胰岛素抵抗、肥胖和生育能力下降，所有这些都可以通过外源性瘦素给药而逆转。

● 无边缘效应：所有孵育步骤在常温下进行消除了37°C下蒸发的风险

● 检测范围广：易于定量检测高水平和低水平瘦素

● 方便：所有试剂保存在4°C

● 快速：仅需3小时就可获得39个样本的重复结果

● 预包被板和即用型试剂为您节省实验时间

产品信息

产品货号	ADI-900-015A   /   欣博盛生物
产品名称	Leptin (rat), ELISA kit（大鼠瘦素ELISA试剂盒）
规格	96 wells
灵敏度	67.2 pg/ml
检测范围	100- 6,400 pg/ml
检测时间	3 hours
样本种属	Rat
样本类型	culture supernatants, plasma, and serum
保存温度	+4°C
试剂盒组分	Microtiter plate, Standard, Antibody, Conjugate, Assay buffer 28, TMB Substrate, Stop solution 2, Wash buffer concentrate

部分产品引用文献

1. Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT::Cre+ rats: C.P. Mantanona, et al.; Brain Struct. Funct. 224, 3095 (2019) 

2. Long-term feeding of red algae (Gelidium amansii) ameliorates glucose and lipid metabolism in a high fructose diet-impaired glucose tolerance rat model: H.C. Liu, et al.; J. Food Drug Anal. 25, 543 (2017), Application(s): Determination of leptin, rat plasma 

3. Melatonin supplementation plus exercise behavior ameliorate insulin resistance, hypertension and fatigue in a rat model of type 2 diabetes mellitus: M.M. Rahman, et al.; Biomed. Pharmacother. 92, 606 (2017) 

4. Effect of Intermittent Hypoxia on Arcuate Nucleus in the Leptin-Deficient Rat: J. Ciriello, et al.; Neurosci. Lett. 626, 112 (2016), Application(s): Measured leptin levels in rat aqueous plasma phase 

5. Neonatal treatment with scopolamine butylbromide prevents metabolic dysfunction in male rats: A. Malta, et al.; Sci. Rep. 6, 30745 (2016), Application(s): Leptin level quantification 

6. Impact of prenatal exposure to obesogenic environment on later-life brown and white adipocytes and liver outcomes: L. Bezpalko, et al.; Proc. Shevchenko Sci. Soc. Medicine 41, 33 (2015), Application(s): ELISA using rat serum 

7. Lactobionic acid reduces body weight gain in diet-induced obese rats by targeted inhibition of galectin-1: R. Mukherjee, et al.; Biochem. Biophys. Res. Commun. 463, 1311 (2015), Application(s): ELISA using rat plasma